Quinuclidine → 1-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

HRID 970307Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970307
[Br:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]=[S:7].[N:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2>C(#N)C>[Br-:1].[N:5]([CH2:4][CH2:3][CH2:2][N+:8]12[CH2:15][CH2:14][CH:11]([CH2:12][CH2:13]1)[CH2:10][CH2:9]2)=[C:6]=[S:7]

Komponenten

4

Edukt 2

HCID 7527QuinuclidineHCID 1377143-Bromopropyl isothiocyanate

Produkt 1

HCID 231542151-(3-Isothiocyanatopropyl)-1-azoniabicyclo[2.2.2]octane bromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 55 mg of 3-bromopropyl isothiocyanate in 1 ml of acetonitrile was added 33 mg of quinuclidine, and the mixture was heated at 50° C for 19 hours. The reaction solution was concentrated and the residue was washed 3 times with 1 ml of ether to obtain the title compound.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. washthe residue was washed 3 times with 1 ml of ether

Quellen und Nachweise

ORD-Eintrag
ord-fdf8a04abea84e4085a51cac43632810
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312208B2

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