Methanol → 4-(9-Thia-1,5,7-triaza-fluoren-8-yl)-piperazine-1-carbothioic acid [4-(Pyrimidin-2-ylsulfamoyl)-phenyl]-amide

HRID 970461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 970461
[N:1]1([C:7]2[C:8]3[S:15][C:14]4[N:16]=[CH:17][CH:18]=[CH:19][C:13]=4[C:9]=3[N:10]=[CH:11][N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.N1C=CC=CC=1.[Cl-].[N:27]1[CH:32]=[CH:31][CH:30]=[N:29][C:28]=1[NH:33][S:34]([C:37]1[CH:42]=[CH:41][C:40]([NH:43][CH:44]=[S:45])=[CH:39][CH:38]=1)(=[O:36])=[O:35].CO>ClCCl>[N:27]1[CH:32]=[CH:31][CH:30]=[N:29][C:28]=1[NH:33][S:34]([C:37]1[CH:42]=[CH:41][C:40]([NH:43][C:44]([N:4]2[CH2:3][CH2:2][N:1]([C:7]3[N:12]=[CH:11][N:10]=[C:9]4[C:8]=3[S:15][C:14]3[N:16]=[CH:17][CH:18]=[CH:19][C:13]4=3)[CH2:6][CH2:5]2)=[S:45])=[CH:39][CH:38]=1)(=[O:36])=[O:35]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 1049PyridineHCID 673902864-Piperazinopyrido[3',2';4,5]thieno[3,2-d]pyrimidineHCID 86601004N-Pyrimidin-2-yl-4-thioformylamino-benzenesulfonamide chloride

Produkt 1

HCID 590205024-(9-Thia-1,5,7-triaza-fluoren-8-yl)-piperazine-1-carbothioic acid [4-(Pyrimidin-2-ylsulfamoyl)-phenyl]-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 4-piperazinopyrido[3′,2′;4,5]thieno[3,2-d] pyrimidine (200 mg, 0.74 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1d in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 60 mg (15%).

Aufarbeitung

  1. customto quench excess thiophosgene
  2. customthe residue after removal of solvent
  3. customwas purified by silica gel column chromatography
  4. washeluting with 5% methanol/dichloromethane
  5. customfurther recrystallized from dichloromethane/hexane
  6. customto give 60 mg (15%)

Quellen und Nachweise

ORD-Eintrag
ord-3ec4dad119134d8a992ed11f7c9ec430
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312226B2

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