Nitric Acid → 1-Chloro-5-nitroisoquinoline

HRID 970667

Reaktionsgleichung

Reaktionsgleichung von HRID 970667
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[N+:12]([O-])([OH:14])=[O:13].[N+]([O-])([O-])=O.[K+]>OS(O)(=O)=O>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 24434Potassium NitrateHCID 140539Isoquinoline, 1-chloro-

Produkt 1

HCID 4597741-Chloro-5-nitroisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A mixture of 1-chloroisoquinoline (6.0 g, 0.037 mol) in conc. H2SO4 (35 mL) was treated with a solution of fuming HNO3 (10 mL) and potassium nitrate (4.0 g, 0.040 mol) in conc. H2SO4 (35 mL) at 0-5° C. The mixture was stirred at 0° C. for a further 90 min, and poured into ice. The precipitate was collected, washed and dried to give the product as a yellow solid. LC-MS: 3.68 min, 209.2 & 211.1 (M+1).

Aufarbeitung

  1. additionpoured into ice
  2. customThe precipitate was collected
  3. washwashed
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b5ac563706ea427f81b60b2abccc3ca5
Quelldatensatz
uspto-grants-2007_12
Patentnummer
US07312233B2

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