N-((Phenylmethoxy)carbonyl)glycine 4-nitrophenyl ester → HCID 131709998, Verbindung

HRID 971572

Reaktionsgleichung

Reaktionsgleichung von HRID 971572
[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][C:9]([NH:11][CH2:12][C:13]([O:15]C2C=CC([N+]([O-])=O)=CC=2)=O)=[O:10])=[CH:3][CH:2]=1.[NH2:25][C@H:26]([C:28]([N:30]1[CH2:41][CH2:40][CH2:39][C@H:31]1[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[O:29])[CH3:27].C(Cl)(Cl)Cl.CO>C(OCC)(=O)C>[NH:11]([C:9]([O:8][CH2:7][C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)=[O:10])[CH2:12][C:13]([NH:25][C@H:26]([C:28]([N:30]1[CH2:41][CH2:40][CH2:39][C@H:31]1[C:32]([O:34][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:33])=[O:29])[CH3:27])=[O:15]

Komponenten

5

Edukt 3

HCID 15616N-((Phenylmethoxy)carbonyl)glycine 4-nitrophenyl esterHCID 12939800tert-Butyl L-alanyl-L-prolinateHCID 21584188Chloroform methanol

Produkt 1

HCID 131709998HCID 131709998, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

1.65 g of Z-Gly-ONP and 1.09 g of H-Ala-Pro-OtBu in 20 ml of ethyl acetate are allowed to stand for one hour at 0° C. and 20 hours at room temperature. The mix is then diluted with ethyl acetate, washed with 50% saturated potassium carbonate solution and with water, dried over sodium sulphate and evaporated. 2.06 g of an oil which is homogeneous according to thin layer chromatography result. Rf = 0.8 in the system chloroform-methanol (1:1) on silica gel.

Aufarbeitung

  1. washwashed with 50% saturated potassium carbonate solution and with water
  2. dry with materialdried over sodium sulphate
  3. customevaporated
  4. customresult

Quellen und Nachweise

ORD-Eintrag
ord-14775f8a1a9f48ada785abe31afbeddb
Quelldatensatz
uspto-grants-1979_07
Patentnummer
US04159981

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