Benzoyl chloride → HCID 21313390, Verbindung

HRID 971801Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 971801
[CH:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClCCCC(=O)CCCC.C(=O)([O-])[O-].[K+].[K+].C1(CC2CCCCN2CCCC(=O)CCCC)CCCCC1.COC1C=CC(NN)=CC=1.C1(CC2CCCCN2[CH2:75][CH2:76][C:77]2[C:85]3[C:80](=[CH:81][CH:82]=[C:83]([O:86][CH3:87])[CH:84]=3)[NH:79][C:78]=2[CH2:88][CH2:89][CH2:90][CH3:91])CCCCC1.[H-].[Na+].[Na].[C:95](Cl)(=[O:102])[C:96]1[CH:101]=[CH:100][CH:99]=[CH:98][CH:97]=1>C(O)C.CN(C=O)C>[C:95]([N:79]1[C:80]2[C:85](=[CH:84][C:83]([O:86][CH3:87])=[CH:82][CH:81]=2)[C:77]([CH2:76][CH2:75][N:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH:8]2[CH2:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)=[C:78]1[CH2:88][CH2:89][CH2:90][CH3:91])(=[O:102])[C:96]1[CH:101]=[CH:100][CH:99]=[CH:98][CH:97]=1

Komponenten

12

Edukt 9

HCID 7412Benzoyl chlorideHCID 11430Potassium CarbonateHCID 24758Sodium hydrideHCID 77023(4-Methoxyphenyl)hydrazineHCID 44333382-(Cyclohexylmethyl)piperidineHCID 5360545SodiumHCID 108990074-Octanone, 1-chloro-HCID 21313399HCID 21313399, VerbindungHCID 21313413HCID 21313413, Verbindung

Produkt 1

HCID 21313390HCID 21313390, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittel2×HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1-Benzoyl-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-butylindole is prepared by reaction of 2-cyclohexylmethylpiperidine with 1-chlorooctan-4-one in ethanol in the presence of anhydrous potassium carbonate; reaction of the resulting 1-(2-cyclohexylmethylpiperidino)octan-4-one with 4-methoxyphenylhydrazine in ethanol; and reaction of the resulting 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-butylindole with sodium hydride in DMF followed by reaction of the resulting sodium salt with benzoyl chloride all according to the procedure described above in Example 1.

Quellen und Nachweise

ORD-Eintrag
ord-2f69df30e976475d9d945fd5ae8388ef
Quelldatensatz
uspto-grants-1979_07
Patentnummer
US04160862

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