Sodium Hydroxide → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea
Reaktionsgleichung
C([NH:9][C:10]([NH:12][CH:13]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>>[S:18]1[CH:19]=[CH:20][C:21]2[CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15][CH2:16][C:17]1=2Komponenten
3
Versuchsvorschrift
A mixture of 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl) urea and 2N aqueous sodium hydroxide solution (5ml) is stirred at reflux for 2.5 hours. The mixture is cooled in ice, the product is collected and washed with water to afford 0.58 g of title compound, m.p. 203° to 207° C.
Aufarbeitung
- temperatureat reflux for 2.5 hours
- temperatureThe mixture is cooled in ice
- customthe product is collected
- washwashed with water
Quellen und Nachweise
- ORD-Eintrag
- ord-14391dd763914b96a03eb547db6e1b88
- Quelldatensatz
- uspto-grants-1977_10
- Patentnummer
- US04053484
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