p-Piperidinophenol → HCID 21405650, Verbindung

HRID 972890Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 972890
[Na].[N:2]1([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Br[CH:16]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:17]([O:19]CC)=[O:18]>C(O)C>[C:22]1([CH:16]([O:14][C:11]2[CH:10]=[CH:9][C:8]([N:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)=[CH:13][CH:12]=2)[C:17]([OH:19])=[O:18])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 90452p-PiperidinophenolHCID 97780Ethyl bromophenylacetateHCID 5360545Sodium

Produkt 1

HCID 21405650HCID 21405650, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.3 g. of sodium is dissolved in 100 ml. of absolute ethanol; 17.7 g. of 4-piperidinophenol is introduced into the solution, and then 24.3 g. of ethyl α-bromophenylacetate is added dropwise thereto and the mixture refluxed for 10 hours. The reaction mixture is then evaporated, the residue mixed with water, and the aqueous solution extracted with ethyl acetate. The ethyl acetate solution is washed twice with dilute KOH and twice with water, then dried, and the solvent is evaporated, thus obtaining the ethyl ester of α-phenyl-α-4-piperidinophenoxy-acetic acid; hydrochloride, m.p. 149°-151°.

Aufarbeitung

  1. temperaturethe mixture refluxed for 10 hours
  2. customThe reaction mixture is then evaporated
  3. additionthe residue mixed with water
  4. extractionthe aqueous solution extracted with ethyl acetate
  5. washThe ethyl acetate solution is washed twice with dilute KOH and twice with water
  6. customdried
  7. customthe solvent is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-99c6fc8562064e6bad38c78bb67fceca
Quelldatensatz
uspto-grants-1977_10
Patentnummer
US04053626

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