Ethyl 7-bromoheptanoate → 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

HRID 973192Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 973192
C(OC(COC1C=CC(F)=CC=1)C#CCNS(C)(=O)=O)(=O)C.C(OC(COC1C=CC(F)=CC=1)CCCNS(C)(=O)=O)(=O)C.BrCCCCCCC(OCC)=O.BrCC#CCCCC(OCC)=O.C([O:72][CH:73]([CH2:93][O:94][C:95]1[CH:100]=[CH:99][C:98]([F:101])=[CH:97][CH:96]=1)[C:74]#[C:75][CH2:76][N:77]([CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][C:88]([O:90]CC)=[O:89])[S:78]([CH3:81])(=[O:80])=[O:79])(=O)C>>[OH:72][CH:73]([CH2:93][O:94][C:95]1[CH:100]=[CH:99][C:98]([F:101])=[CH:97][CH:96]=1)[C:74]#[C:75][CH2:76][N:77]([CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][C:88]([OH:90])=[O:89])[S:78]([CH3:81])(=[O:80])=[O:79]

Komponenten

6

Edukt 5

HCID 122490Ethyl 7-bromoheptanoateHCID 15174663Ethyl 7-bromohept-5-ynoateHCID 21401584N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamideHCID 21401585HCID 21401585, VerbindungHCID 21401631ethyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoate

Produkt 1

HCID 214015787-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

Versuchsvorschrift

This compound is prepared by the procedure described in Example 2, Step I, except that N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamide is substituted for the N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamide and ethyl 7-bromoheptanoate is substituted for ethyl 7-bromo-5-heptynoate. The product is thus ethyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoate. The subsequent hydrolysis (Example 2, Step J) affords the subject compound.

Aufarbeitung

  1. customThis compound is prepared by the procedure
  2. customThe subsequent hydrolysis (Example 2, Step J)
  3. customaffords the subject compound

Quellen und Nachweise

ORD-Eintrag
ord-05af4a35b53741a0a86223c8470cbfad
Quelldatensatz
uspto-grants-1977_10
Patentnummer
US04055596

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