Phosphorus oxychloride → 4-Chloroquinazolin-2-amine
Reaktionsgleichung
[NH2:1][C:2]1[NH:11][C:10](=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.P(Cl)(Cl)([Cl:15])=O>>[NH2:1][C:2]1[N:11]=[C:10]([Cl:15])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1Komponenten
3
Versuchsvorschrift
2-Amino-4-(3H)-quinazolone (2.0 g, 0.0124 mol) was heated under reflux in phosphoryl chloride (19.02 g, 0.0124 mol) for 2.5 hours. The reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9) and the organic phase dried, filtered, excess solvent removed and the residue triturated with chloroform to give 2-amino-4-chloroquinazoline (0.42 g, 19%) m.p. 275°-278°.
Aufarbeitung
- customThe reaction mixture was partitioned between chloroform, ice and NaOH solution (pH 9)
- customthe organic phase dried
- filtrationfiltered
- customexcess solvent removed
- customthe residue triturated with chloroform
Quellen und Nachweise
- ORD-Eintrag
- ord-a00b58d881d04dd3ad21ea4e7e30bf0e
- Quelldatensatz
- uspto-grants-1991_11
- Patentnummer
- US05064833
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