Sodium Chloride → HCID 15667144, Verbindung

HRID 973770

Reaktionsgleichung

Reaktionsgleichung von HRID 973770
[Na].[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7](Cl)=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1.[O-:28][CH2:29][CH2:30][CH3:31].[Na+].[Cl-]>C(O)CC>[CH3:2][C@@H:3]1[C@@H:21]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:6]2[C:7]([O:28][CH2:29][CH2:30][CH3:31])=[N:8][C:9]3[N:13]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:12]=[CH:11][C:10]=3[C:5]2=[N:4]1

Komponenten

6

Edukt 4

HCID 5234Sodium ChlorideHCID 5360545SodiumHCID 125435151-Propanol, ion(1-)HCID 15667140HCID 15667140, Verbindung

Produkt 1

HCID 15667144HCID 15667144, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10311-PropanolLösungsmittel2×

Versuchsvorschrift

51 mg sodium was dissolved in 5 ml n-propanol. 670 mg of the above product (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-chloro-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine dissolved in 15 ml n-propanol was added to the propoxide solution with stirring. After 1 hour the reaction was poured into 200 ml saturated NaCl and the extracts were dried over MgSO4, filtered and concentrated to yield an oil which was purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate) to yield 600 mg of (2R-trans)-2,7-dihydro-2-methyl-3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine.

Aufarbeitung

  1. dry with materialthe extracts were dried over MgSO4
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customto yield an oil which
  5. customwas purified by radial chromatography (30-50-70-90% ethanol/ hexane, 2 mm plate)

Quellen und Nachweise

ORD-Eintrag
ord-977b111411004781a6cca546565ac9e0
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05064947

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