Hydrochloric Acid → Methyl 1H-pyrazole-4-carboxylate

HRID 973903Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 973903
Cl.[NH:2]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[N:3]1.[CH3:10]O>>[C:7]([C:5]1[CH:6]=[N:2][NH:3][CH:4]=1)([O:9][CH3:10])=[O:8]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3015937Pyrazole-4-carboxylic acid

Produkt 1

HCID 9793760Methyl 1H-pyrazole-4-carboxylateAusbeute 79,6 %

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To an ice cold saturated solution of HCl in methanol (500 ml), pyrazole-4-carboxylic acid (4) (19.2 g, 0.17 m) was added and the solution stirred at 0° C. for 3 hours and at ambient temperature overnight. The solvent was distilled off and the brown residue was dissolved in water. The aqueous solution was neutralized with NaHCO3 and the product was repeatedly extracted with ether (25×100 ml). The ether extract was dried over Mg SO4 and concentrated to give the methyl ester (5) as a pale yellow solid (13.59 g, 79.6%).

Aufarbeitung

  1. distillationThe solvent was distilled off
  2. dissolutionthe brown residue was dissolved in water
  3. extractionthe product was repeatedly extracted with ether (25×100 ml)
  4. extractionThe ether extract
  5. dry with materialwas dried over Mg SO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9d6c41211e5a4b94b67faddd3872272f
Quelldatensatz
uspto-grants-1991_11
Patentnummer
US05066479

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