HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl Acetate → 2-Amino-6-(1,2-dihydronaphthalen-3-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl Acetate | HCID 8857 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 3-(Chloromethyl)-1,2-dihydronaphthalene | HCID 12771433 | — |
| Edukt | 2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine | HCID 19985785 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-Amino-6-(1,2-dihydronaphthalen-3-yl-methyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine | HCID 19985928 | 29% |
Reaktionsschritte
Prepared from 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine, potassium carbonate and 3-chloromethyl-1,2-dihydronaphthalene (prepared from 1,2-dihydronaphthalene, paraformaldehyde and concentrated hydrochloric acid) in anhydrous dimethylformamide for 2 hours at 50° C. Yield: 29% of theory, Melting point: 158°-160° C. (ethyl acetate).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05068325 |
| Quelldatensatz | uspto-grants-1991_11 |
| ORD ID | ord-61b79b84cbeb4667a54a7c8ecbf62d05 |
| Quellennotiz | uspto-grants-1991_11 |