2,4-Dimethoxytetrahydrofuran → 1H-Pyrrole, 1-[3-(2,4-difluorophenyl)propyl]-

Beteiligte Stoffe

Reaktionsschritte

17.1 g (0.10 mol) of 3-(2,4-difluorophenyl)propylamine are heated at 260° C. for 2 hours in an autoclave with 13.2 g (0.10 mol) of 2,4-dimethoxytetrahydrofuran. The reaction mixture is cooled and then purified by vacuum distillation. 10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained.

Herkunft & Nachweise