Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dione → 6-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine

HRID 974903

Reaktionsgleichung

Reaktionsgleichung von HRID 974903
[CH2:1]([N:8]1[C:16](=O)[CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][CH2:14]2)[C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][CH2:14]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 9899604Tetrahydro-6-(phenylmethyl)-1H-pyrrolo(3,4-b)pyridine-5,7(2H,6H)-dioneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 113563766-Benzyloctahydro-1H-pyrrolo[3,4-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

44 g (about 0.18 mol ) of crude or pure 6-benzyl-5,7-dioxo-octahydropyrrolo[3,4-b]pyridine are reduced with 15.2 g (0.40 mol ) of lithium aluminum hydride in 390 ml of absolute tetrahydrofuran in the course of 10 hours in accordance ,with the working instructions of Example Ic. 24.4 g of a colorless oil having a boiling point of 93°-95° C./0.06 mbar are obtained on distillation.

Aufarbeitung

  1. customare obtained on distillation

Quellen und Nachweise

ORD-Eintrag
ord-e1a125ff3382415c9802b8ff8a4bb1b3
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05607942

Verknüpfte Notizen

Wird geladen…