Sodium Bicarbonate → 4-Methyl-5-propionyloxazole

HRID 975038

Reaktionsgleichung

Reaktionsgleichung von HRID 975038
CON(C)[C:4]([C:6]1[O:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:5].[CH2:13]([Mg]Br)[CH3:14].C(=O)([O-])O.[Na+]>O1CCCC1>[CH3:11][C:7]1[N:8]=[CH:9][O:10][C:6]=1[C:4](=[O:5])[CH2:13][CH3:14]

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 18925369N-Methoxy-N,4-dimethyloxazole-5-carboxamideHCID 178418443HCID 178418443, Verbindung

Produkt 1

HCID 189363294-Methyl-5-propionyloxazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

N-Methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (5 g) in dry tetrahydrofuran at -40° C. was stirred under a nitrogen atmosphere and ethylmagnesium bromide (1M solution in tetrahydrofuran, 35 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and then stirred for a further 1 hour. Aqueous sodium hydrogen carbonate was added, the organic layer was separated and the aqueous layer was extracted with diethylether. The material thus obtained was purified by flash chromatography to yield a pale yellow liquid which solidified on cooling.

Aufarbeitung

  1. customthe organic layer was separated
  2. extractionthe aqueous layer was extracted with diethylether
  3. customThe material thus obtained
  4. customwas purified by flash chromatography
  5. customto yield a pale yellow liquid which
  6. temperatureon cooling

Quellen und Nachweise

ORD-Eintrag
ord-14f1b749a0f249299ac8e0e73b1a91bb
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05607956

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