Trifluoroacetic acid → 6-[3-(4-(aminoiminomethyl)phenylamino)-3-oxopropyl]-3,4,5,6-tetrahydro-2H-pyran-2-one

HRID 976334

Reaktionsgleichung

Reaktionsgleichung von HRID 976334
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:20])[CH2:11][CH2:12][CH:13]2[O:18][C:17](=[O:19])[CH2:16][CH2:15][CH2:14]2)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O.CC#[N:30].CCOCC>>[NH2:30][N:2]=[CH:1][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:20])[CH2:11][CH2:12][CH:13]2[O:18][C:17](=[O:19])[CH2:16][CH2:15][CH2:14]2)=[CH:7][CH:8]=1

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 190366276-[3-(4-cyanophenylamino)-3-oxopropyl]-3,4,5,6-tetrahydro-2H-pyran-2-oneHCID 21885917Acetonitrile ether

Produkt 1

HCID 700779716-[3-(4-(aminoiminomethyl)phenylamino)-3-oxopropyl]-3,4,5,6-tetrahydro-2H-pyran-2-one

Versuchsvorschrift

The title compound was prepared from the product of step B (770 mg, 2.83 mmol) in a manner similar to example 1, step G to give 430 mg (38%) of product as TFA salt after reverse phase chromatography and trituration with CH3CN/Et2O (m.p. 151°-153° C. dec.).

Quellen und Nachweise

ORD-Eintrag
ord-5e3249e1962f4e75ad970cf575400a0c
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05612355

Verknüpfte Notizen

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