6-Amino-3-methyl-2-methylsulfanyl-5-nitrosopyrimidin-4-one → 5,6-Diamino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
Reaktionsgleichung
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[N:12]=O>[NH4+]=S>[NH2:12][C:3]1[C:4](=[O:11])[N:5]([CH3:10])[C:6]([S:8][CH3:9])=[N:7][C:2]=1[NH2:1]Komponenten
2
Versuchsvorschrift
To 4.0 g (0.02 mole) of 6-amino-3-methyl-2-methylthio-5-nitroso-pyrimidine-4-one (44) was added 40 mL of 20% aqueous ammonium sulfide solution. The mixture was heated under reflux for 30 min. After cooling the precipitate was collected, washed with a little ethanol and dried in a desiccator to give 45 as 2.72 g (75% yield) of colorless crystals (m.p. 211°-212° C.).
Aufarbeitung
- temperatureThe mixture was heated
- temperatureunder reflux for 30 min
- temperatureAfter cooling the precipitate
- customwas collected
- washwashed with a little ethanol
- customdried in a desiccator
Quellen und Nachweise
- ORD-Eintrag
- ord-04ca4354890e41f89c29f6bc0da8aba2
- Quelldatensatz
- uspto-grants-1997_03
- Patentnummer
- US05612468
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