2-Fluoromethyl-2-phthalimido-5-iodopentanenitrile → 2-Fluoromethyl-2,5-diphthalimidopentanenitrile

HRID 977299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 977299
[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8]I)[C:4]#[N:5].[C:21]1(=[O:31])[NH:25][C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12.[K]>CN(C)C=O>[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8][N:25]1[C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]2[C:21]1=[O:31])[C:4]#[N:5]

Komponenten

4

Edukt 2

HCID 147716572-Fluoromethyl-2-phthalimido-5-iodopentanenitrileHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 199663332-Fluoromethyl-2,5-diphthalimidopentanenitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-Fluoromethyl-2-phthalimido-5-iodo-valeronitrile (1.20 g, 3.11 mmol) and potassium phthalimide (0.75 g, 4 mmol) are heated in dimethylformamide (25 mL) to 80° C. for 2 hours. After standing overnight at room temperature, the DMF is removed by vacuum distillation and the residue is dissolved in chloroform and washed with 1N KOH and water. After drying (Na2SO4), evaporation gives 2-fluoromethyl-2,5-diphthalimido-valeronitrile as a solid.

Aufarbeitung

  1. customthe DMF is removed by vacuum distillation
  2. dissolutionthe residue is dissolved in chloroform
  3. washwashed with 1N KOH and water
  4. customAfter drying
  5. custom(Na2SO4), evaporation

Quellen und Nachweise

ORD-Eintrag
ord-967551eef0d04158a459b7d3dbdef65e
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05614557

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