N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamide → N-[2-ethyl-6-(1-hydroxy-3-phenylpropyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

HRID 977823Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 977823
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]=[O:10])[C:4]=1[NH:11][C:12](=[O:28])[CH2:13][CH:14]1[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:21][C:20]2[C:15]1=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:2].[CH2:29]([Mg]Br)[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([OH:10])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:4]=1[NH:11][C:12](=[O:28])[CH2:13][CH:14]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[O:21][C:22]2[C:27]1=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:2]

Komponenten

3

Edukt 2

HCID 19966259N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamideHCID 178419670HCID 178419670, Verbindung

Produkt 1

HCID 19966244N-[2-ethyl-6-(1-hydroxy-3-phenylpropyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

Versuchsvorschrift

Following a procedure similar to that described in Example 14, but using N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamide (prepared by a procedure similar to that described in Preparation 29) and phenethylmagnesium bromide as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as crystals, melting at 128°-129° C. (after recrystallization from a mixture of ethyl acetate and hexane).

Aufarbeitung

  1. customprepared by a procedure similar to

Quellen und Nachweise

ORD-Eintrag
ord-aeb6bd010d5944e299986373a928d0d0
Quelldatensatz
uspto-grants-1997_03
Patentnummer
US05614550

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