Ethyl bromoacetate → Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

HRID 978104Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 978104
[CH3:1][C:2]([C:4]1[C:5]([OH:11])=[CH:6][CH:7]=[CH:8][C:9]=1[OH:10])=[O:3].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:17]([O:16][C:14](=[O:15])[CH2:13][O:11][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([OH:10])[C:4]=1[C:2](=[O:3])[CH3:1])[CH3:18]

Komponenten

5

Edukt 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 696872',6'-Dihydroxyacetophenone

Produkt 1

HCID 4673143Ethyl (2-acetyl-3-hydroxyphenoxy)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 2,6-dihydroxyacetophenone (40 g), ethyl bromoacetate (48 g) and potassium carbonate (58 g) in acetone (500 ml) was refluxed for 3 hours. The mixture was cooled and filtered. The solution was evaporated to dryness and the crude solid extracted with boiling hexane. Upon cooling, the title compound was obtained.

Aufarbeitung

  1. temperaturewas refluxed for 3 hours
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. customThe solution was evaporated to dryness
  5. extractionthe crude solid extracted with boiling hexane
  6. temperatureUpon cooling

Quellen und Nachweise

ORD-Eintrag
ord-5daafc56e4054350848aa44c9f5eec5d
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04663347

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