Sodium Hydroxide → E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acid

HRID 978119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 978119
[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[C:7]2[C:8]([CH3:18])=[C:9](/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 13849545Ethyl (E)-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate

Produkt 1

HCID 13849550E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoic acidAusbeute 96,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl-E-3-(4-hydroxy-3-methylbenzofuran-2-yl)propenoate (225 mg, 0.9 mmoles) (From Example 159), 2N sodium hydroxide (4 ml) and methanol (15 ml) was stirred at room temperature for 36 hours. The mixture was concentrated, acidified with 20% citric acid solution and extracted with ether. The ether solution was dried with Na2SO4, filtered and concentrated to obtain 190 mg of the title compound, m.p. 246°-248° C. (dec.).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. extractionextracted with ether
  3. dry with materialThe ether solution was dried with Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5d4c08c195b64b72b2ba6a5bd5e0b2db
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04663347

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