Rolziracetam → 3-(5-Oxopyrrolidin-2-yl)propanoic acid

HRID 978196

Reaktionsgleichung

Reaktionsgleichung von HRID 978196
C1C2N(C(=O)CC2)C(=O)C1.O[N:12]=[C:13]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:14][CH2:15][C:16](O)=[O:17]>>[O:17]=[C:16]1[NH:12][CH:13]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:14][CH2:15]1

Komponenten

3

Edukt 2

HCID 71893RolziracetamHCID 202053364-(Hydroxyimino)heptanedioic acid

Produkt 1

HCID 45856673-(5-Oxopyrrolidin-2-yl)propanoic acid

Versuchsvorschrift

In accordance with the present invention an improved process for preparing dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione comprises the steps of first catalytically hydrogenating a mono(lower alkyl) ester of 4-(hydroxyimino)heptanedioic acid in the presence of a tertiary lower alkyl amine to produce 5-oxo-2-pyrrolidinepropanoic acid, and thereafter heating the 5-oxo-2-pyrrolidinepropanoic acid in the presence of a cyclizing agent to form dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione.

Quellen und Nachweise

ORD-Eintrag
ord-4e2ddfd77d124ab6b351a15db992b3bd
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04663464

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