Sodium Hydroxide → 2-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolane

HRID 978436Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 978436
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[O:14][CH2:13][CH2:12][O:11]2)[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([C:10]2([CH:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)[O:14][CH2:13][CH2:12][O:11]2)=[CH:16][CH:17]=1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 191009161-Acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine

Produkt 1

HCID 132790992-(4-Fluorophenyl)-2-(4-piperidyl)1,3-dioxolaneAusbeute 82 %

Versuchsvorschrift

A mixture of 5 parts of 1-acetyl-4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine and 100 parts of a sodium hydroxide solution 10% was stirred and refluxed overnight. The reaction mixture was cooled and the product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The solid residue was stirred in 2,2'-oxybispropane. The product was filtered off and dried in vacuo at 40° C., yielding 3.5 parts (82%) of 4-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]piperidine (2).

Aufarbeitung

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture was cooled
  3. extractionthe product was extracted with trichloromethane
  4. customThe extract was dried
  5. filtrationfiltered
  6. customevaporated
  7. stirringThe solid residue was stirred in 2,2'-oxybispropane
  8. filtrationThe product was filtered off
  9. customdried in vacuo at 40° C.

Quellen und Nachweise

ORD-Eintrag
ord-3121c6604aeb4d80b453b9e1b0855870
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04665075

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