HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Boron trifluoride etherate → N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Boron trifluoride etherate | HCID 8000 | — |
| Edukt | 2,2,4,4-Tetramethylpentan-3-ol | HCID 139790 | — |
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | Benzyl 2-methylaziridine-1-carboxylate | HCID 21895246 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane | HCID 20201216 | — |
Reaktionsschritte
N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04666729 |
| Quelldatensatz | uspto-grants-1987_05 |
| ORD ID | ord-ac71cc7775c045aa8166b0c6f8206357 |
| Quellennotiz | uspto-grants-1987_05 |