Bromoacetyl chloride → 6-(Bromoacetyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

HRID 979056

Reaktionsgleichung

Reaktionsgleichung von HRID 979056
[Br:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][N:7]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]1=[O:17].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[Br:1][CH2:2][C:3]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:17])[N:7]([CH3:6])[CH2:16]2)=[O:4]

Komponenten

5

Edukt 3

HCID 89602Bromoacetyl chlorideHCID 38465583,4-Dihydro-3-methyl-2(1H)-quinazolinoneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 138271656-(Bromoacetyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6348Carbon DisulfideLösungsmittel

Versuchsvorschrift

Bromoacetyl chloride (4.8 g) is added dropwise to a stirring solution of 3,4-dihydro-3-methyl-2(1H)-quinazolinone (2.5 g) and anhydrous aluminum chloride (4.9 g) in carbon disulfide (50 ml) under nitrogen. The reaction mixture is refluxed for five hours, cooled to RT and the carbon disulfide decanted. The residue is treated with hydrochloric acid (6N) and the acidic residue poured into ice water, stirred and filtered. The filtered solid is washed with water and dried in vacuo, affording the desired product, which is used in the next step without further purification, M.P. 190°-200° C. (dec).

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for five hours
  2. customthe carbon disulfide decanted
  3. additionThe residue is treated with hydrochloric acid (6N)
  4. additionthe acidic residue poured into ice water
  5. filtrationfiltered
  6. washThe filtered solid is washed with water
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-98d69d64549a406cbdea5fa4bc3c32bb
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04666913

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