2-Butoxyaniline → Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate

HRID 979111

Reaktionsgleichung

Reaktionsgleichung von HRID 979111
CS[C:3]1[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=1.[CH2:15]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH2:22])[CH2:16][CH2:17][CH3:18]>N1C=CC=CC=1>[CH2:15]([O:19][C:20]1[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=1[NH:22][C:3]1[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=1)[CH2:16][CH2:17][CH3:18]

Komponenten

4

Edukt 2

HCID 1382652-ButoxyanilineHCID 239049Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate

Produkt 1

HCID 13562779Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylateAusbeute 60,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (21.5 g) and 2-butoxyaniline (24 g) are added to pyridine (50 ml), and the mixture is refluxed with stirring for 18 hours. The reaction mixture is concentrated to dryness. The residue is recrystallized from DMF to give ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate (20 g). M.p. 209°-211° C.

Aufarbeitung

  1. temperaturethe mixture is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness
  3. customThe residue is recrystallized from DMF

Quellen und Nachweise

ORD-Eintrag
ord-c6b4e61da94b46858d0e79b139946c45
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04666915

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