HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Butyl 4-aminobenzoate → Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Butyl 4-aminobenzoate | HCID 2482 | — |
| Edukt | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate | HCID 13562812 | 41,7% |
Reaktionsschritte
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (10 g) and butyl -4-aminobenzoate (10.8 g) are added to ethanol (100 ml), and the mixture is refluxed with stirring for 48 hours. After cooling, the precipitate is collected by filtration and recrystallized from a mixture of DMF and water to give ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate (7.0 g). M.p. 281°-283° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04666915 |
| Quelldatensatz | uspto-grants-1987_05 |
| ORD ID | ord-af91b5896fc74264967fab2191b6c057 |
| Quellennotiz | uspto-grants-1987_05 |