Dicyclohexylcarbodiimide → HCID 131715158, Verbindung

HRID 979445Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 979445
C1(N=C=NC2CCCCC2)CCCCC1.[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1>N1C=CC=CC=1>[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1

Komponenten

5

Edukt 3

HCID 10868DicyclohexylcarbodiimideHCID 768066-CarboxyfluoresceinHCID 4140301AC1N56UX

Produkt 1

HCID 131715158HCID 131715158, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

N,N'-dicyclohexylcarbodiimide (15 mg) was added to a solution of 8-β-aminoethyltheophylline (5 mg) and carboxyfluorescein (5 mg) in 0.5 ml of pyridine. The reaction was allowed to proceed for two hours at room temperature and the reaction product was purified twice employing silica gel thin-layer chromatography using a thin chloroform:methanol (2:1) mixture as developing solvent to yield an 8-β-amino ethyltheophylline-carboxyfluorescein conjugate of the formula: ##STR10##

Aufarbeitung

  1. customthe reaction product was purified twice employing silica gel thin-layer chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9f33ce5de7f64bda89ddf3b2b500a09f
Quelldatensatz
uspto-grants-1987_05
Patentnummer
US04668640

Notizen zur Reaktion

Wird geladen…