4-Fluorophenyl isocyanate → HCID 20223045, Verbindung

HRID 979780

Reaktionsgleichung

Reaktionsgleichung von HRID 979780
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:18]=[O:19])=[CH:13][CH:12]=1>N1C=CC=CC=1>[F:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:7]2[C:8](=[O:9])[NH:1][C:2](=[S:3])[NH:4][C:5]=2[OH:6])=[O:19])=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 709554-Fluorophenyl isocyanateHCID 2723628Thiobarbituric acid

Produkt 1

HCID 20223045HCID 20223045, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

2-thiobarbituric acid (14.4 g) was suspended in pyridine and 4-fluorophenyl isocyanate (13.7 g) was added thereto. The reaction mixture was maintained at 90° C. for one hour, and thereafter left overnight at room temperature. The solids formed were collected, washed with pyridine, re-suspended in ethanol, and again collected and dried. A pale pink powder product was thereby obtained, mp >250° C. (dec.), NMR (DMSO) 7.0-7.7δ (multiplet, integral 4); 10.7-11.4δ (overlapping broad singlets, combined integral 4). MS, M/e 281 (Calc., 281).

Aufarbeitung

  1. customThe solids formed
  2. customwere collected
  3. washwashed with pyridine
  4. customagain collected
  5. customdried
  6. customA pale pink powder product was thereby obtained

Quellen und Nachweise

ORD-Eintrag
ord-8411a693a2244562bb1b98915c09dac2
Quelldatensatz
uspto-grants-1987_01
Patentnummer
US04634707

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