Dimethylformamide dimethyl acetal → Ethyl 2-(2-chloro-6,7,8-trifluoro-3-quinolinecarbonyl)(dimethylamino)acrylate

HRID 981197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981197
[Cl:1][C:2]1[C:11]([C:12](=[O:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:10][C:9]2[C:4](=[C:5]([F:22])[C:6]([F:21])=[C:7]([F:20])[CH:8]=2)[N:3]=1.CO[CH:25](OC)[N:26]([CH3:28])[CH3:27]>C(OCC)(=O)C>[Cl:1][C:2]1[C:11]([C:12]([C:13](=[CH:25][N:26]([CH3:28])[CH3:27])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:19])=[CH:10][C:9]2[C:4](=[C:5]([F:22])[C:6]([F:21])=[C:7]([F:20])[CH:8]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 53987966Ethyl 3-(2-chloro-6,7,8-trifluoro-3-quinolyl)-3-oxopropionate

Produkt 1

HCID 53994177Ethyl 2-(2-chloro-6,7,8-trifluoro-3-quinolinecarbonyl)(dimethylamino)acrylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A suspension of 26.7 g of ethyl 3-(2-chloro-6,7,8-trifluoro-3-quinolyl)-3-oxopropionate in 270 cm3 of ethyl acetate and 32 cm3 of N,N-dimethylformamide dimethyl acetal is heated at a temperature close to 75° C., with stirring, for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure (20 kPa) at about 50° C. The dry extract is taken up in 175 cm3 of diisopropyl ether, drained and washed with twice 85 cm3 of the same solvent. 19.32 g of ethyl 2-(2-chloro-6,7,8-trifluoroquinoline-3-carbonyl)-3-dimethylaminoacrylate are obtained in the form of an orange solid melting at 118° C., which is used for the subsequent steps without further purification.

Aufarbeitung

  1. temperatureis heated at a temperature
  2. customclose to 75° C.
  3. concentrationThe reaction mixture is concentrated to dryness under reduced pressure (20 kPa) at about 50° C
  4. extractionThe dry extract
  5. washwashed with twice 85 cm3 of the same solvent

Quellen und Nachweise

ORD-Eintrag
ord-41fe0a417b2e4f75848dfdf37931487c
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04990515

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