Ethanol → Benzoic acid, 2,4-dichloro-5-fluoro-, ethyl ester
Reaktionsgleichung
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:13]([OH:15])[CH3:14]>>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([O:15][CH2:13][CH3:14])=[O:5]Komponenten
3
Versuchsvorschrift
84 g of 2,4-dichloro-5-fluoro-benzoyl chloride are added dropwise to 250 ml of anhydrous ethanol at 50° to 60° C., the temperature being maintained by occasional cooling with ice-water. The mixture is then refluxed for about a further hour, the excess alcohol is distilled off and the residue is fractionated in vacuo. 84.9 g (~97%) of ethyl 2,4-dichloro-5-fluoro-benzoate are obtained at 132°-135° C./8 mbar.
Aufarbeitung
- temperaturethe temperature being maintained
- temperatureThe mixture is then refluxed for about a further hour
- distillationthe excess alcohol is distilled off
Quellen und Nachweise
- ORD-Eintrag
- ord-84f4a811032d4a7ea1669fb806d713ad
- Quelldatensatz
- uspto-grants-1991_02
- Patentnummer
- US04990646
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