HCID 14330456, Verbindung → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 981668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981668
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

Komponenten

3

Edukt 1

HCID 14330456HCID 14330456, Verbindung

Produkt 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 10 g of N-t-butoxycarbonyl-3,4-di-hydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 mL of trifluoroacetic acid is kept at room temperature for 1 hr. The solvent is removed in vacuo, the residue is treated with 1N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine as an oil.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b32ddaf38ea34cc9917debca97a47687
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992465

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