Qing Hau Sau → Artemisinic Acid

HRID 981776

Reaktionsgleichung

Reaktionsgleichung von HRID 981776
[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C:13]([C:15]([OH:17])=[O:16])=[CH2:14])[CH2:4][CH2:3]1.[CH3:18][C@H:19]1[C@@H:29]2[CH2:30][CH2:31][C@:32]3([CH3:36])O[O:35][C@:28]42[C@H:22]([C@@H:23]([CH3:37])[C:24]([O:26][C@@H:27]4[O:33]3)=[O:25])[CH2:21][CH2:20]1>>[CH3:1][C@H:2]1[C@@H:7]2[CH2:8][CH2:9][C:10]([CH3:12])=[CH:11][C@@H:6]2[C@H:5]([C:13]([C:15]([OH:17])=[O:16])=[CH2:14])[CH2:4][CH2:3]1.[CH3:18][C@H:19]1[C@@H:29]2[CH2:30][CH2:31][C@:32]3([CH3:36])[O:35][C:28]42[C@H:22]([C@@H:23]([CH3:37])[C:24]([O:26][C@@H:27]4[O:33]3)=[O:25])[CH2:21][CH2:20]1

Komponenten

4

Edukt 2

HCID 9838675Qing Hau Sau2×HCID 10922465Artemisinic Acid2×

Produkt 2

HCID 10922465Artemisinic AcidHCID 45038803Desoxyartemisinin

Versuchsvorschrift

Because there is far more artemisinic acid (Compound 1) than artemisinin (Compound 3) in Artemisia annua, the conversion of the former to the latter has received a great deal of attention. Prior synthetic conversion of 1 to 3 required a greater number of steps, produced a yield of approximately 7% and required the use of column chromatography for purification of the resulting artemisinin. Other attempts to simplify the process resulted in conversion of artemisinic acid into desoxyartemisinin, but did not . result in conversion to artemisinin.

Aufarbeitung

  1. customproduced a yield of approximately 7%
  2. customfor purification of the resulting artemisinin

Quellen und Nachweise

ORD-Eintrag
ord-b7d7bdaa31024d2f88bbb35879aa4a83
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04992561

Verknüpfte Notizen

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