Methylamine → 2(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-

HRID 981910Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 981910
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](Cl)=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].[CH3:20][NH2:21]>O1CCCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([NH:21][CH3:20])=[C:7]([N+:16]([O-:18])=[O:17])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 99709251-Butyl-4-chloro-3-nitroquinolin-2(1H)-one

Produkt 1

HCID 100847802(1H)-Quinolinone, 1-butyl-4-(methylamino)-3-nitro-Ausbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

11 g (0.039 mole) of Compound d obtained in Reference Example 4 was dissolved in 100 ml of tetrahydrofuran, and 30 ml (0.39 mole) of 40% methylamine was added with ice cooling, followed by stirring at room temperature for one hour. Then, the solvent was evaporated under reduced pressure, and water was added to the residues. The precipitate was collected by filtration and dried, to afford 9.2 g of Compound w (yield: 87%).

Aufarbeitung

  1. customThen, the solvent was evaporated under reduced pressure, and water
  2. additionwas added to the residues
  3. filtrationThe precipitate was collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f3f84304477a4b1daecbafdedaab4c43
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04994468

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