Benzenesulfonamide, 4-methyl-N-phenyl- → N-[4-[(1-acetyl-4-piperidinyl)carbonyl]phenyl]Methanesulfonamide

HRID 982355

Reaktionsgleichung

Reaktionsgleichung von HRID 982355
C1(C)C=C[C:4]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(=[O:9])=[O:8])=CC=1.[C:18]([N:21]1[CH2:29][CH2:28][CH:24]([C:25](Cl)=[O:26])[CH2:23][CH2:22]1)(=[O:20])[CH3:19].C(N1CCCC(C(Cl)=O)C1)(=O)C1C=CC=CC=1>>[C:18]([N:21]1[CH2:22][CH2:23][CH:24]([C:25](=[O:26])[C:14]2[CH:13]=[CH:12][C:11]([NH:10][S:7]([CH3:4])(=[O:8])=[O:9])=[CH:16][CH:15]=2)[CH2:28][CH2:29]1)(=[O:20])[CH3:19]

Komponenten

4

Edukt 3

HCID 2456Benzenesulfonamide, 4-methyl-N-phenyl-HCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 15718173N-benzoylnipecotoyl chloride

Produkt 1

HCID 14130038N-[4-[(1-acetyl-4-piperidinyl)carbonyl]phenyl]Methanesulfonamide

Versuchsvorschrift

The same procedure as above was repeated except that methanesulfonamilide was replaced with p-toluenesulfonanilide or 1-acetylisonipecotoyl chloride was replaced with (±)-N-benzoylnipecotoyl chloride or (±)-N-benzoyl-β-prolyl chloride prepared in Referential Example 2 to obtain the following compounds:

Aufarbeitung

  1. customprepared in Referential Example 2
  2. customto obtain the following compounds

Quellen und Nachweise

ORD-Eintrag
ord-988a5fe0588949808d1ed8199a9ee096
Quelldatensatz
uspto-grants-1991_02
Patentnummer
US04996215

Verknüpfte Notizen

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