Methanol → 1,3-bis(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl)amino]phenoxy)-2,2-bis[(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl)amino]phenoxy)methyl]propane

HRID 982596

Reaktionsgleichung

Reaktionsgleichung von HRID 982596
Cl[C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10]2[CH:69]=[CH:68][C:13]([O:14][CH2:15][C:16]([CH2:51][O:52][C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60]4[N:65]=[C:64](Cl)[N:63]=[C:62](Cl)[N:61]=4)=[CH:55][CH:54]=3)([CH2:34][O:35][C:36]3[CH:41]=[CH:40][C:39]([NH:42][C:43]4[N:48]=[C:47](Cl)[N:46]=[C:45](Cl)[N:44]=4)=[CH:38][CH:37]=3)[CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]4[N:31]=[C:30](Cl)[N:29]=[C:28](Cl)[N:27]=4)=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)[N:3]=1.[CH2:70]([NH2:78])[CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77].[OH-].[Na+].CO>O1CCOCC1>[CH2:70]([NH:78][C:2]1[N:7]=[C:6]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:5]=[C:4]([NH:9][C:10]2[CH:69]=[CH:68][C:13]([O:14][CH2:15][C:16]([CH2:51][O:52][C:53]3[CH:58]=[CH:57][C:56]([NH:59][C:60]4[N:65]=[C:64]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:63]=[C:62]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:61]=4)=[CH:55][CH:54]=3)([CH2:34][O:35][C:36]3[CH:41]=[CH:40][C:39]([NH:42][C:43]4[N:48]=[C:47]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:46]=[C:45]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:44]=4)=[CH:38][CH:37]=3)[CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([NH:25][C:26]4[N:31]=[C:30]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:29]=[C:28]([NH:78][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77])[N:27]=4)=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)[N:3]=1)[CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH3:77]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 8143OctylamineHCID 14798Sodium HydroxideHCID 220154391,3-bis(4-[N-(2,4-dichloro-1,3,5-triazin-6-yl)amino]phenoxy)-2,2-bis[(4-[N-(2,4-dichloro-1,3,5-triazin-6-yl)amino]phenoxy)methyl]propane

Produkt 1

HCID 220154331,3-bis(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl)amino]phenoxy)-2,2-bis[(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl)amino]phenoxy)methyl]propaneAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of 1,3-bis(4-[N-(2,4-dichloro-1,3,5-triazin-6-yl)amino]phenoxy)-2,2-bis[(4-[N-(2,4-dichloro-1,3,5triazin-6-yl)amino]phenoxy)methyl]propane (3.88 grams, 3.55 mmol; prepared as described in Part D of this Example) and octylamine (11.7 milliliters, 71.0 mmol; obtained from Aldrich Chemical Co.) in dioxane (30 milliliters) was heated at reflux for 3 hours. The mixture was then cooled and added to 400 milliliters of a solution of 1 Normal NaOH and methanol (1:1 (v/v)). The resulting white solid was filtered off and dissolved in tetrahydrofuran. This solution was filtered over silica gel, and the volatiles were removed under reduced pressure. The residue was triturated in methanol and then dried under vacuum to afford pure 1,3-bis(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl) amino]phenoxy)-2,2-bis[(4-[N-(2,4-bis(N-octylamino)-1,3,5-triazin-6-yl)amino]phenoxy)methyl]propane 14.50 grams, 2.45 mmol, 69 percent yield) as white powder: softening point 94-96° C.; IR (KBr) 3434, 3274, 2925, 2854, 1579, 1506, 1421, 1367, 1226, 1030, 810 cm−1; 1H NMR (400 MHz, DMSO-d6, 373° K) δ8.11 (s, 4H), 7.60 (d. 8H. 3J=8.9 Hz), 6.84 (d, 8H, 3J=8.9 Hz), 6.12 (s, 8H), 4.25 (s, 8H), 3.26 (td, 16H. 3Jt=6.6 Hz, 3Jd=6.6 Hz), 1.53 (m, 16H), 1.29 (m, 80H), 0.86 (t, 24H, 3J=7.1 Hz); 13C NMR (100 MHz, DMSO-d6, 373° K) δ165.54, 163.77, 153.31, 133.96, 120.76, 114.27, 67.15, 44.47, 39.61, 30.56, 28.87, 28.14, 27.96, 25.90, 21.29, 13.00; MS (FAB, 3-nitrobenzyl alcohol) m/e 1834.6; Anal. Calcd for C105H172N24O4: C, 68.74; H, 9.45; N, 18.32. Found: C, 68.31; H, 9.58: N, 18.34.

Aufarbeitung

  1. customprepared
  2. temperaturewas heated
  3. temperatureat reflux for 3 hours
  4. temperatureThe mixture was then cooled
  5. filtrationThe resulting white solid was filtered off
  6. dissolutiondissolved in tetrahydrofuran
  7. filtrationThis solution was filtered over silica gel
  8. customthe volatiles were removed under reduced pressure
  9. customThe residue was triturated in methanol
  10. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0c350b05eac94eed9b4c3dad5c114b0b
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06860928B2

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