HCID 20765950, Verbindung → HCID 21949492, Verbindung
Reaktionsgleichung
[C:1]([CH2:3][CH:4]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([S:14](Cl)(=O)=O)[CH:11]=2)[O:6][CH2:5]1)#[N:2].CC1N=C(C2C=CC(C(F)(F)F)=CC=2)SC=1CSC1C=C2C(=CC=1)OCC(CC#N)C2>>[SH:14][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[O:6][CH2:5][CH:4]([CH2:3][C:1]#[N:2])[CH2:13]2Komponenten
3
Versuchsvorschrift
Compound 18E was prepared according to the method of example 1C utilizing compound 18D. Compound 18E was prepared in 35% yield. MS: 204 (M−1)+. Preparation of 6-[4-Methyl-2-(4-trifluoromethyl-pheny)-thiazol-5-ylmethylsulfanyl]-chroman-3-yl-acetonitrile (Compound 18F)
Aufarbeitung
- customCompound 18E was prepared
Quellen und Nachweise
- ORD-Eintrag
- ord-f539debde3384d11b08e0cfe5f568505
- Quelldatensatz
- uspto-grants-2005_03
- Patentnummer
- US06867224B2
Notizen zur Reaktion
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