5-Mercapto-Indan-2-Carboxylic Acid Methyl Ester → (5-Mercapto-6-methoxy-indan-1-yl)-acetic acid ethyl ester
Reaktionsgleichung
[CH3:1]OC(C1CC2C(=CC=C(S)C=2)C1)=O.[CH3:15][O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([S:30]CC3SC(C4C=CC(C(F)(F)F)=CC=4)=NC=3C)=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1>>[CH2:15]([O:16][C:17](=[O:48])[CH2:18][CH:19]1[C:27]2[C:22](=[CH:23][C:24]([SH:30])=[C:25]([O:28][CH3:29])[CH:26]=2)[CH2:21][CH2:20]1)[CH3:1]Komponenten
3
Versuchsvorschrift
19C was prepared analogously to compound 1C. Used as unpurified oil. MS: 267 (M+1)+. Preparation of {6-Methoxy-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-indan-1-yl}-acetic acid methyl ester (Compound 19D)
Quellen und Nachweise
- ORD-Eintrag