3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 1-(tert-butoxycarbonyl)-4-[N-[4-(trifluoromethyl)phenyl]-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

HRID 984276Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 984276
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([C:37]2[CH:38]=[C:39]([CH:42]=[CH:43][CH:44]=2)[CH2:40]Cl)[CH:30]=[C:31]([O:35][CH3:36])[C:32]=1[O:33][CH3:34]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=2)[CH2:40][C:39]2[CH:42]=[CH:43][CH:44]=[C:37]([C:29]3[CH:30]=[C:31]([O:35][CH3:36])[C:32]([O:33][CH3:34])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH:38]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 120211573-(3,4,5-Trimethoxyphenyl)benzyl chlorideHCID 220291421-Boc-4-(4-Trifluoromethyl-phenylamino)-piperidine

Produkt 1

HCID 225580191-(tert-butoxycarbonyl)-4-[N-[4-(trifluoromethyl)phenyl]-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]piperidine

Versuchsvorschrift

1-(tert-Butoxycarbonyl)-4-[[4-(trifluoromethyl)phenyl]amino]piperidine (689 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (586 mg) was treated in the same manner as described in Example 9 to give light yellow amorphous of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-a5156e6cd1644ec3a73d96964ba41c84
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06867221B2

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