Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Ethylene Glycol | HCID 174 | — |
| Edukt | Benzylamine | HCID 7504 | — |
| Edukt | 2-Chlorobenzoic Acid | HCID 8374 | — |
| Edukt | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | 2-((Phenylmethyl)amino)benzoic acid | HCID 81095 | 48% |
Reaktionsschritte
Copper(I) iodide (19 mg, 0.10 mmol), K3PO4 (636 mg, 3.00 mmol), benzylamine (131 μL, 1.20 mmol), 2-chlorobenzoic acid (157 mg, 1.00 mmol), ethylene glycol (111 μL, 2.00 mmol) and 1-butanol (1.0 mL) were used and heated to 100° C. for 72 hours. The above workup procedure was followed and gave 2-(N-benzyl)aminobenzoic acid (109 mg, 48% isolated yield) as a light yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06867298B2 |
|---|
| Quelldatensatz | uspto-grants-2005_03 |
|---|
| ORD ID | ord-69bcb8a3f39e42ef84e3e0e6082caffa |
|---|
| Quellennotiz | uspto-grants-2005_03 |
|---|
