Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Ethylene Glycol | HCID 174 | — |
| Edukt | 2-Iodobenzoic acid | HCID 6941 | — |
| Edukt | Benzylamine | HCID 7504 | — |
| Edukt | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | 2-((Phenylmethyl)amino)benzoic acid | HCID 81095 | 71% |
Reaktionsschritte
Copper(I) iodide (10 mg, 0.05 mmol), K3PO4 (636 mg, 3.00 mmol), benzylamine (131 μL, 1.20 mmol), 2-iodobenzoic acid (248 mg, 1.00 mmol), ethylene glycol (111 μL, 2.00 mmol) and 2-propanol (1.0 mL) were used and heated at 80° C. for 18 hours. The above workup procedure was followed and gave 2-(N-benzyl)aminobenzoic acid (161 mg, 71% isolated yield) as a light yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06867298B2 |
|---|
| Quelldatensatz | uspto-grants-2005_03 |
|---|
| ORD ID | ord-7c533e3b527c407584e755a2c5fd07d0 |
|---|
| Quellennotiz | uspto-grants-2005_03 |
|---|
