Sodium methanesulfinate → HCID 22508876, Verbindung

HRID 984862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 984862
[F:1][C:2]1[C:10]([O:11][C:12]2[C:17]3=[C:18]([CH3:26])[C:19]([O:21][CH2:22][CH:23]4[CH2:25][O:24]4)=[CH:20][N:16]3[N:15]=[CH:14][N:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:27])[NH:6]2.[CH3:28][S:29]([O-:31])=[O:30].[Na+]>CS(C)=O>[F:1][C:2]1[C:10]([O:11][C:12]2[C:17]3=[C:18]([CH3:26])[C:19]([O:21][CH2:22][CH:23]([OH:24])[CH2:25][S:29]([CH3:28])(=[O:31])=[O:30])=[CH:20][N:16]3[N:15]=[CH:14][N:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:27])[NH:6]2

Komponenten

4

Edukt 2

HCID 2733271Sodium methanesulfinateHCID 22508879HCID 22508879, Verbindung

Produkt 1

HCID 22508876HCID 22508876, VerbindungAusbeute 45,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

A mixture of Example 2 (10 mg, 0.027 mmol) and sodium methanesulfinate (120 mg, 85%, 1.0 mmol) in DMSO was heated at 105° C. for 1 hr. The mixture was concentrated and purified by chromatography on silica gel eluting with 5% methanol in ethyl acetate to provide the title compound (5.5 mg, 45%) as a white solid. MS: (M+H)+=449.3

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. custompurified by chromatography on silica gel eluting with 5% methanol in ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-65bfb135a8974d5fb62262d11fa6de25
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06869952B2

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