HCID 22321559, Verbindung → 4-(chloromethyl)-1-methyl-1H-1,2,3-triazole hydrochloride
Reaktionsgleichung
O.[ClH:2].[CH3:3][N:4]1[CH:8]=[C:7]([CH2:9]O)[N:6]=[N:5]1>S(Cl)(Cl)=O>[ClH:2].[Cl:2][CH2:9][C:7]1[N:6]=[N:5][N:4]([CH3:3])[CH:8]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To thionyl chloride (20 ml) under nitrogen, cooled by an ice bath, was added (1-methyl-1H-[1,2,3]triazol-4-yl)methanol hydrochloride monohydrate (1.996 g, 11.9 mmol). The mixture was stirred for 5 min before removing the cooling bath and heating at reflux for 30 min. The excess thionyl chloride was evaporated in vacuo and the residue was triturated with diethyl ether. The resulting solid was collected by filtration, washed with diethyl ether and dried under vacuum at 60° C. to give the title compound as a white solid: 1H NMR (360 MHz, DMSO-d6) δ 4.04 (3H, s), 4.81 (2H, s), 8.13 (1H, s).