Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

HRID 985648

Reaktionsgleichung

Reaktionsgleichung von HRID 985648
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].Cl[C@H:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]>[Cl-].C([N+](CCCCCC)(CCCCCC)CCCCCC)CCCCC>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C@@H:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 149593Methyl 2-chloropropanoate, (R)-

Produkt 1

HCID 10125210Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80021Tetrahexylammonium chlorideKatalysator

Versuchsvorschrift

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-chloropropionate (92 mg) and tetrahexylammonium chloride (40 mg). As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 56 mg (36%) of the title compound.

Aufarbeitung

  1. customIn accordance with the process of Example 2, a condensation reaction

Quellen und Nachweise

ORD-Eintrag
ord-6cf3c6d98bf442c9a6a83c5c04dd5378
Quelldatensatz
uspto-grants-2005_03
Patentnummer
US06872823B1

Verknüpfte Notizen

Wird geladen…