Enprofylline → HCID 14014540, Verbindung

HRID 985943

Reaktionsgleichung

Reaktionsgleichung von HRID 985943
[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=O)[NH:6][C:5]1=[O:14])[CH2:2][CH3:3].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16]>N1C=CC=CC=1>[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=[S:16])[NH:6][C:5]1=[O:14])[CH2:2][CH3:3]

Komponenten

4

Edukt 2

HCID 1676EnprofyllineHCID 14817Phosphorus sulfide (P2S5)

Produkt 1

HCID 14014540HCID 14014540, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel2×

Versuchsvorschrift

A suspension of 9.32 g. (48 mM.) of 3-propylxanthine in 80 ml. of pyridine, was treated with 17.33 g. (78 mM.) of phosphorus pentasulfide in 80 ml. of pyridine, and worked up analogously to Example I. 8.9 g. of 3-propyl-6-thioxanthine was obtained. Recrystallization from methanol-acetone gave 7.4 g. (59% yield) of needles with a melting point of 249°-250° C.

Aufarbeitung

  1. additionA suspension of 9.32 g

Quellen und Nachweise

ORD-Eintrag
ord-d2a3177f855d42d6a0dcc040f2a3c249
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04710503

Verknüpfte Notizen

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