4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline → 2-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline

HRID 986068

Reaktionsgleichung

Reaktionsgleichung von HRID 986068
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](OC)[C:3]=1[C:11]1[O:12][CH2:13][C:14]([CH3:17])([CH3:16])[N:15]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([Mg]Br)=[CH:21][CH:20]=1.COC1C=CC=CC=1C1OCC(C)(C)N=1.COC1C=CC=CC=1[Mg]Br>>[Cl:1][C:2]1[C:3]([C:11]2[O:12][CH2:13][C:14]([CH3:17])([CH3:16])[N:15]=2)=[C:4]([C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

Komponenten

5

Edukt 4

HCID 3331894,4-Dimethyl-2-(2-methoxyphenyl)oxazolineHCID 128028832-(2,4-Dichloro-6-methoxyphenyl)-4,4-dimethyl-2-oxazolineHCID 178418676HCID 178418676, VerbindungHCID 178489560HCID 178489560, Verbindung

Produkt 1

HCID 128028842-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline

Versuchsvorschrift

By substituting equimolar amounts of 2-(2,4-dichloro-6-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 4-fluorophenylmagnesium bromide for 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 2-methoxyphenylmagnesium bromide, the title compound was prepared following the procedure of Example 17, Step A, (85%), mp 93°-95° C.

Quellen und Nachweise

ORD-Eintrag
ord-f8a353aafcc1481e86df9107b4a806d0
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04710513

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