Thionyl Chloride → 3-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

HRID 986429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 986429
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16]O)=[CH:10][CH:9]=2)[CH:2]=1.S(Cl)([Cl:20])=O>C(Cl)Cl>[ClH:20].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][Cl:20])=[CH:10][CH:9]=2)[CH:2]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 138227803-[4-(Pyridin-3-ylmethyl)phenyl]propanol

Produkt 1

HCID 201486293-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 10 ml of methylene chloride was dissolved 500 mg of 3-[4-(pyridin-3-ylmethyl)phenyl]propanol, and 0.80 ml of thionyl chloride was added to the resulting solution with ice-cooling, after which the resulting mixture was subjected to reaction under reflux for one hour. The solvent and the excessive thionyl chloride were removed by distillation under reduced pressure, to obtain 3-[4-(pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride as the residue. This residue was dissolved in 4 ml of dimethyl sulfoxide.

Aufarbeitung

  1. additionwas added to the resulting solution with ice-
  2. temperaturecooling
  3. customafter which the resulting mixture was subjected to reaction
  4. temperatureunder reflux for one hour
  5. customThe solvent and the excessive thionyl chloride were removed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b4e700d2813443a7ac9f8b27169f01d1
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04713387

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