Thionyl Chloride → 3-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

HRID 986439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 986439
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16]O)=[CH:10][CH:9]=2)[CH:2]=1.S(Cl)([Cl:20])=O>C(Cl)Cl>[ClH:20].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][Cl:20])=[CH:10][CH:9]=2)[CH:2]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 138227803-[4-(Pyridin-3-ylmethyl)phenyl]propanol

Produkt 1

HCID 201486293-[4-(Pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In 10 ml of methylene chloride was dissolved 2.04 g of 3-[4-(pyridin-3-ylmethyl)phenyl]propanol, and 3.26 ml of thionyl chloride was added dropwise to the resulting solution with ice-cooling, after which the resulting mixture was subjected to reaction under reflux for one hour. The solvent and the excessive thionyl chloride were removed by distillation under reduced pressure to obtain oily 3-[4-(pyridin-3-ylmethyl)phenyl]propyl chloride hydrochloride.

Aufarbeitung

  1. additionwas added dropwise to the resulting solution with ice-
  2. temperaturecooling
  3. customafter which the resulting mixture was subjected to reaction
  4. temperatureunder reflux for one hour
  5. customThe solvent and the excessive thionyl chloride were removed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-292037f3ebbb481887b2182338c0e331
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04713387

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