Sodium Hydroxide → 7-Thienylamino-1H-pyrazolo[4,3-b]pyridine
Reaktionsgleichung
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[C:12](C(OCC)=O)=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12.[OH-].[Na+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (0.600 g) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure and the residue diluted with water (5 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered off and dried, mp 255°-259° C.
Aufarbeitung
- temperatureby heating
- customThe ethanol was removed under reduced pressure
- additionthe residue diluted with water (5 ml)
- filtrationThe resulting acid was filtered off
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-795da91dd8ec4d3bba0d28a4380803d5
- Quelldatensatz
- uspto-grants-1987_12
- Patentnummer
- US04716160
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