Hydrochloric Acid → 2-Amino-4-phenylbutyrate ethyl hydrochloride

HRID 986774

Reaktionsgleichung

Reaktionsgleichung von HRID 986774
[NH2:1][CH:2]([C:11]([OH:13])=[O:12])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:14].[CH2:15](O)[CH3:16]>>[ClH:14].[NH2:1][CH:2]([CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[C:11]([O:13][CH2:15][CH3:16])=[O:12]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 102530Homophenylalanine, DL-

Produkt 1

HCID 533952832-Amino-4-phenylbutyrate ethyl hydrochloride

Versuchsvorschrift

A suspension of d,l-homophenylalanine (5 g., 27.9 mmole) in absolute ethanol (60 ml.) was cooled to 0° (ice bath) and saturated with hydrochloric acid gas. The mixture was allowed to warm to room temperature and stirred overnight. A stream of nitrogen was then passed through the solution to remove the bulk of the hydrochloric acid and the mixture was evaporated to dryness. The solid residue was triturated with ether, filtered and dried to give (±)-α-aminobenzenebutanoic acid, ethyl ester, monohydrochloride as a fluffy white solid; m.p. 129°-130°. Rf (acetic acid/methanol/dichloromethane; 1:1:8)=0.63.

Aufarbeitung

  1. temperaturewas cooled to 0° (ice bath)
  2. customto remove the bulk of the hydrochloric acid
  3. customthe mixture was evaporated to dryness
  4. customThe solid residue was triturated with ether
  5. filtrationfiltered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-18d49c616b4e489b9d2506c44a303e72
Quelldatensatz
uspto-grants-1987_12
Patentnummer
US04716155

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